Insulin-like growth factor-I prevents development of a vincristine neuropathy in mice
โ Scribed by Patricia C Contreras; Jeffry L Vaught; John A Gruner; Celia Brosnan; Cathy Steffler; Joseph C Arezzo; Michael E Lewis; John A Kessler; Stuart C Apfel
- Book ID
- 114003624
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 444 KB
- Volume
- 774
- Category
- Article
- ISSN
- 0006-8993
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Both neurons and glia succumb to programmed cell death (PCD) when deprived of growth factors at critical periods in development or following injury. Insulin-like growth factor-I (IGF-I) prevents apoptosis in neurons in vitro. To investigate whether IGF-I can protect Schwann cells (SC) from apoptosis