✦ LIBER ✦

Insulin-like growth factor-I prevents apoptosis in neurons after nerve growth factor withdrawal

✍ Scribed by Russell, James W. ;Windebank, Anthony J. ;Schenone, Angelo ;Feldman, Eva L.

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 273 KB
Volume: 36
Category: Article
ISSN: 0022-3034
DOI: 10.1002/(sici)1097-4695(19980915)36:4<455::aid-neu1>3.0.co;2-v

No coin nor oath required. For personal study only.

✦ Synopsis

Insulin-like growth factor-I (IGF-NGF withdrawal. The antiapoptotic effect of IGF-I I) is emerging as an important growth factor able to was completely blocked by LY294002, an inhibitor of modulate the programmed cell death (PCD) pathway mediated by the cysteine-dependent aspartate prote-PI 3-kinase signaling, but not by the mitogen-activated ases (caspases); however, little is known about the protein (MAP) kinase/extracellular signal-regulated effect of IGF-I after nerve growth factor (NGF) withprotein kinase (ERK) activated protein kinase inhibidrawal in neurons. To begin to understand the neutor PD98059. Functional IGF-I receptors were extenronal death-sparing effect of IGF-I under NGF-free sively expressed both in rat and human DRG neurons, conditions, we tested whether embryonic sensory doralthough they were most abundant in the neuronal sal root ganglion neurons (DRG) were able to survive growth cone. Collectively, these findings indicate that in defined serum-free medium in the presence of IGF-IGF-I, signaling though the PI-3 kinase pathway, is I. We further studied the role of IGF-I signaling and important in modulating PCD in cultured DRG neucaspase inhibition after NGF withdrawal. NGF withrons after NGF withdrawal, and IGF-I may be imdrawal produced histological changes of apoptosis inportant in DRG embryogenesis. ᭧ 1998 John Wiley & cluding chromatin condensation, shrinkage of the per-

📜 SIMILAR VOLUMES

Insulin-like growth factor-I prevents ca

Insulin-like growth factor-I prevents caspase-mediated apoptosis in Schwann cells

✍ Delaney, Catherine L. ;Cheng, Hsin-Lin ;Feldman, Eva L. 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 100 KB 👁 2 views

Both neurons and glia succumb to programmed cell death (PCD) when deprived of growth factors at critical periods in development or following injury. Insulin-like growth factor-I (IGF-I) prevents apoptosis in neurons in vitro. To investigate whether IGF-I can protect Schwann cells (SC) from apoptosis

Insulin-like growth factor family in mal

Insulin-like growth factor family in malignant haemangiopericytomas: the expression and role of insulin-like growth factor I receptor

✍ Paveli?, Kre?imir; Paveli?, Zlatko P.; Cabrijan, Tomislav; Karner, Ivan; Samar?i 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 235 KB 👁 2 views

Haemangiopericytoma is a rare soft tissue tumour originating from the contractile pericapillary cells. Relatively little is known about its molecular pathogenesis. To address this issue, the insulin-like growth factor family (IGFs) was analysed in 19 tumours collected from a human tumour bank networ

Insulin-like growth factor I is the key

Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis

✍ Cynthia M. Van Golen; Eva L. Feldman 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 249 KB 👁 2 views

Neuroblastoma is a childhood tumor of the peripheral nervous system that remains largely uncurable by conventional methods. Mannitol induces apoptosis in neuroblastoma cell types and insulin-like growth factor I (IGF-I) protects these cells from hyperosmotic-induced apoptosis by affecting apoptosis-

Serum insulin-like growth factor-I, insu

Serum insulin-like growth factor-I, insulin-like growth factor binding protein-3, and the pubertal growth spurt in the female rhesus monkey

✍ Stanley J. Ulijaszek 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 179 KB 👁 1 views

Insulin-like growth factor I regulates r

Insulin-like growth factor I regulates renal development in rodents

✍ Rogers, Sharon A. ;Powell-Braxton, Lyn ;Hammerman, Marc R. 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 261 KB 👁 1 views

Blocking the action of insulin-like growth factor I (IGF I) impairs kidney development in vitro. However, no renal developmental abnormalities have been reported in newborn transgenic mice that do not express IGF I (Igf1 Ϫ/Ϫ ) mice. Ninety-five percent of Igf1 Ϫ/Ϫ mice die immediately following birt

Differential effects of basic fibroblast

Differential effects of basic fibroblast growth factor, epidermal growth factor, transforming growth factor-α, and insulin-like growth factor-I on a hypothalamic gonadotropin-releasing hormone neuronal cell line

✍ Alejandra Ochoa; Clelia Domenzáin; Carmen Clapp; Gonzalo Martínez de la Escalera 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 418 KB 👁 2 views

Recent studies in several neuronal lineages suggest that extrinsic factors such as polypeptide growth factors regulate various stages of neuronal development, from initial commitment of multipotent progenitors to induction of specific gene expression that is characteristic of terminal neuronal diffe