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Insulin is a potent myeloma cell growth factor through insulin/IGF-1 hybrid receptor activation

✍ Scribed by Sprynski, A C; Hose, D; Kassambara, A; Vincent, L; Jourdan, M; Rossi, J F; Goldschmidt, H; Klein, B

Book ID: 109887236
Publisher: Nature Publishing Group
Year: 2010
Tongue: English
Weight: 742 KB
Volume: 24
Category: Article
ISSN: 0887-6924
DOI: 10.1038/leu.2010.192

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## Abstract The insulin‐like growth factor receptor (IGF‐IR) has been implicated in a number of human tumors, including breast cancer. Data from human breast tumors has demonstrated that IGF‐IR is over‐expressed and hyper‐phosphorylated. Additionally, microarray analysis has shown that IGF‐I treatm