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Natural and synthetic forms of insulin-like growth factor-1 (IGF-1) and the potent derivative, destripeptide IGF-1: Biological activities and receptor binding

✍ Scribed by F.John Ballard; Geoffrey L. Francis; Marina Ross; Christopher J. Bagley; Bruce May; John C. Wallace

Book ID: 115760119
Publisher: Elsevier Science
Year: 1987
Tongue: English
Weight: 381 KB
Volume: 149
Category: Article
ISSN: 0006-291X
DOI: 10.1016/0006-291x(87)90380-9

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## Background and Objectives: We have previously shown that insulin-like growth factor (IGF)-responsive murine sarcomas demonstrate inhibition of local and metastatic disease growth when implanted in an IGF-deficient host animal. In this experiment, we tested whether IGF receptor (IGF-R) and ligan