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The insulin-like growth factor 1 (IGF-1) receptor is a substrate for γ-secretase-mediated intramembrane proteolysis

✍ Scribed by Brian McElroy; James C. Powell; Justin V. McCarthy

Book ID
116295020
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
388 KB
Volume
358
Category
Article
ISSN
0006-291X

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## Abstract The insulin‐like growth factor receptor (IGF‐IR) has been implicated in a number of human tumors, including breast cancer. Data from human breast tumors has demonstrated that IGF‐IR is over‐expressed and hyper‐phosphorylated. Additionally, microarray analysis has shown that IGF‐I treatm