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Insulin degradation in 3T3-L1 adipocytes: Role of the endocytic lysosomal pathway

✍ Scribed by Subal Bishayee; Manjusri Das

Book ID
115705112
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
479 KB
Volume
214
Category
Article
ISSN
0003-9861

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## Abstract Tunicamycin, an antibiotic that inhibits protein glycosylation, elicited a rapid depletion of insulin binding activity at the surface of 3T3‐L1 adipocytes. Disappearance of insulin receptors occurred more rapidly in the presence of tunicamycin than when protein synthesis was inhibited b