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Shikonin Stimulates Glucose Uptake in 3T3-L1 Adipocytes via an Insulin-Independent Tyrosine Kinase Pathway

✍ Scribed by Reiko Kamei; Yoshinori Kitagawa; Michinori Kadokura; Fumiyuki Hattori; Osamu Hazeki; Yousuke Ebina; Tatsuro Nishihara; Shinzo Oikawa

Book ID
115589756
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
182 KB
Volume
292
Category
Article
ISSN
0006-291X

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Nigericin inhibits insulin-stimulated gl
Nigericin inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes
✍ Chih-Ying Chu; Ying-Shun Kao; Jim C. Fong πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 187 KB

## Abstract We used nigericin, a K^+^/H^+^ exchanger, to test whether glucose transport in 3T3‐L1 adipocytes was modulated by changes in intracellular pH. Our results showed that nigericin increased basal but decreased insulin‐stimulated glucose uptake in a time‐ and dose‐dependent manner. Whereas