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Insulin: a novel agent in the pathogenesis of prostate cancer

✍ Scribed by Hanumanthappa Nandeesha

Publisher: Springer Netherlands
Year: 2008
Tongue: English
Weight: 133 KB
Volume: 41
Category: Article
ISSN: 0301-1623
DOI: 10.1007/s11255-008-9440-x

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## Abstract The insulin‐like growth factor (IGF) axis is a complex system composed of 2 mitogenic ligands, IGF‐I and ‐II, 2 receptors, IGF‐1R and IGF‐2R, and 6 binding proteins, IGFBP‐1 to ‐6. The IGFBPs exert their actions through their regulation of IGF bioavailability for IGF receptors. In addit