The Synthesis and Characterization of a Novel Insulin Sensitizing Agent.
β Scribed by Thomas W. von Geldern; Regina P. Brun; Masha Kalmanovich; Denise Wilcox; Peer B. Jacobson
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 16 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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A novel insulin-disubstituted Co(III) protoporphyrin IX, CoPI, where I is insulin and CoP is Co(III) protoporphyrin IX, was prepared by covalently coupling the propionate groups on the porphyrin ring to the Ξ΅-amino groups of B29-Lys on insulin via amide linkages. The FTIR spectra in the amide I regi