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Insertion of chromosome 11 in chromosome 4 resulting in a 5′MLL-3′AF4 fusion gene in a case of adult acute lymphoblastic leukemia

✍ Scribed by Frédéric Morel; Marie-Josée Le Bris; Nathalie Douet-Guilbert; Jérôme Duchemin; Angèle Herry; Geneviève Le Calvez; Véronique Marion; Christian Berthou; Marc De Braekeleer


Book ID
114135598
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
379 KB
Volume
145
Category
Article
ISSN
0165-4608

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## Abstract The formation of a leukemogenic fusion product in hematopoietic malignancies is commonly achieved by chromosomal translocation. Alternate and cytogenetically undetectable mechanisms of fusion transcript generation have been documented for __BCR__–__AB1__, __AML1__–__ETO__, __PML__–__RAR