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Fusion of an AF4-related gene, LAF4, to MLL in childhood acute lymphoblastic leukemia with t(2;11)(q11;q23)

✍ Scribed by Hiwatari, Mitsuteru; Taki, Tomohiko; Taketani, Takeshi; Taniwaki, Masafumi; Sugita, Kenichi; Okuya, Mayuko; Eguchi, Mitsuoki; Ida, Kohmei; Hayashi, Yasuhide


Book ID
110067502
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
182 KB
Volume
22
Category
Article
ISSN
0950-9232

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LAF4, an AF4-related gene, is fused to M
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## Abstract Infant acute lymphoblastic leukemia (ALL) with __MLL__ gene rearrangements is characterized by a proB phenotype and a poor clinical outcome. We analyzed an infant proB ALL with t(2;11)(p15;p14) and an __MLL__ rearrangement on Southern blot analysis. Rapid amplification of cDNA ends–poly

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A new case of translocation t(6;11)(q21;q23) in a patient with therapy-related acute myeloblastic leukemia is reported. The translocation results in fusion of the MLL and AF6q21 genes. The breakpoint with AF6q21 is located within the sequences encoding the AF6q21 fork head motif. The similar locatio