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LAF4, an AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia

✍ Scribed by Anne R.M. von Bergh; H. Berna Beverloo; Paul Rombout; Elisabeth R. van Wering; Margreet H. van Weel; Geoffrey C. Beverstock; Philip M. Kluin; Rosalyn M. Slater; Ed Schuuring

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
324 KB
Volume
35
Category
Article
ISSN
1045-2257

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✦ Synopsis

Abstract

Infant acute lymphoblastic leukemia (ALL) with MLL gene rearrangements is characterized by a proB phenotype and a poor clinical outcome. We analyzed an infant proB ALL with t(2;11)(p15;p14) and an MLL rearrangement on Southern blot analysis. Rapid amplification of cDNA ends–polymerase chain reaction (PCR) and reverse transcriptase‐PCR identified the LAF4 gene mapped on chromosome region 2q11.2–q12 as a fusion partner of the MLL gene. The LAF4 gene was identified previously by its high sequence homology to the AF4 protein and encodes a protein of 1,227 amino acids. The t(4;11)(q21;q23), creating the MLL‐AF4 chimeric transcripts, is the predominant 11q23 chromosome translocation in infant ALL and is associated with an extremely poor prognosis. Our findings further suggest that fusion of MLL to one of the AF4 family members (AF4/LAF4/AF5Q31) might determine a proB‐cell phenotype in infant leukemia. © 2002 Wiley‐Liss, Inc.

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