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Ins(1,4,5)P3 regulates phospholipase Cβ1 expression in cardiomyocytes

✍ Scribed by Oliver Vasilevski; David R. Grubb; Theresa M. Filtz; Sundy Yang; Tiffany J. McLeod-Dryden; Jieting Luo; Divya Karna; Ju Chen; Elizabeth A. Woodcock


Book ID
116985729
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
594 KB
Volume
45
Category
Article
ISSN
0022-2828

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## Abstract PRIP‐1 was isolated as a novel inositol 1,4,5‐trisphosphate [Ins(1,4,5)P~3~] binding protein with a domain organization similar to phospholipase C‐δ1 (PLC‐δ1) but lacking the enzymatic activity. Further studies revealed that the pleckstrin homology (PH) domain of PRIP‐1 is the region re