Inorganic Synthesis of Azoimide, N3H
✍ Scribed by TUTTON, A. E.
- Book ID
- 109421558
- Publisher
- Nature Publishing Group
- Year
- 1892
- Tongue
- English
- Weight
- 265 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/046286a0
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## Abstract [Fluorophenyl‐^3^H(N)] Ocfentanil (1b) and [fluorophenyl‐^3^H(N)] brifentanil [2b] were synthesized by catalytic tritiation of appropriate bromo precursors (1a, 2a). The products were purifled by preparative HPLC and characterized chromatographically and by proton decoupled ^3^H NMR.
The preparation of the title compound, [ 3 H 3 ]CNS-5161, was accomplished in three steps starting with the production of [ 3 H 3 ]iodomethane (CT 3 I). The intermediate N-[ 3 H 3 ]methyl-3-(thiomethylphenyl)cyanamide was prepared in 77% yield by the addition of CT 3 I to 3-(thiomethylphenyl)cyanami