𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of N-(2-chloro-5-methylthiophenyl)- N′-(3-methyl-thiophenyl)- N′-[3H3]methylguanidine, {[3H3]CNS-5161}

✍ Scribed by Andrew R. Gibbs; Hiromi Morimoto; Henry F. VanBrocklin; Philip G. Williams; Anat Biegon

Publisher
John Wiley and Sons
Year
2002
Tongue
French
Weight
89 KB
Volume
45
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

The preparation of the title compound, [ 3 H 3 ]CNS-5161, was accomplished in three steps starting with the production of [ 3 H 3 ]iodomethane (CT 3 I). The intermediate N-[ 3 H 3 ]methyl-3-(thiomethylphenyl)cyanamide was prepared in 77% yield by the addition of CT 3 I to 3-(thiomethylphenyl)cyanamide, previously treated with sodium hydride. Reaction of this tritiated intermediate with 2-chloro-5-thiomethylaniline hydrochloride formed the guanidine compound [ 3 H 3 ]CNS-5161. Purification by HPLC gave the desired labeled product in an overall yield of 9% with >96% radiochemical purity and a final specific activity of 66 Ci mmol À1 .

📜 SIMILAR VOLUMES

Synthesis of [2,3-3H]-n-butyl alcohol
Synthesis of [2,3-3H]-n-butyl alcohol
✍ Dezhu Wu Wenlin Huang; Wen Wang 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 154 KB 👁 2 views
Synthesis of [N-C3H3]-trans-(1R,3S)-(−)-
Synthesis of [N-C3H3]-trans-(1R,3S)-(−)-1-Phenyl-3-N,N-dimethylamino-1,2,3,4-tetrahydronaphthalene (H2-PAT)
✍ Steven D. Wyrick; Andrew M. Myers; Raymond G. Booth; Nora S. Kula; Ross J. Balde 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 210 KB 👁 1 views

## Abstract Subsequent to the discovery that the (+)‐benzomorphan sigma receptor ligands, (+)‐pentazocine and (+)‐N‐allylnormetazocine, stimulated tyrosine hydroxylase activity and dopamine synthesis in rat striatum __in vitro__, we reported a similar effect on a structurally similar series of 1‐ph