✦ LIBER ✦

Initiation and promotion in hepatocarcinogenesis

✍ Scribed by R. Schulte-Hermann

Publisher: Springer-Verlag
Year: 1987
Tongue: English
Weight: 263 KB
Volume: 60
Category: Article
ISSN: 0340-5761
DOI: 10.1007/bf00296976

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✦ Synopsis

Initiation and promotion have been recognized as essential parts of the multi-stage concept of chemical carcinogenesis. In the liver, initiation by genotoxic carcinogens results in appearance of foci of phenotypically altered hepatocytes. Accelerated growth and phenotypic changes of these foci during tumor promotion by phenobarbital are described, and possible mechanisms of initiation and promotion considered.

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