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Initial adjuvant weekly high dose methotrexate with leucovorin rescue in advanced squamous carcinoma of the head and neck

โœ Scribed by Ralph R. Weichselbaum; Daniel Miller; Susan W. Pitman; John Kirkwood


Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
458 KB
Volume
4
Category
Article
ISSN
0360-3016

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## Abstract Eleven patients with squamous carcinoma of the head and neck who were scheduled for surgical resection or endoscopic biopsy of tumor received 15 mg/m^2^ of methotrexate (MTX). Samples of tumor, normal mucosa, and plasma were obtained at surgery or endoscopy, 18โ€24 hours after the last M

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Twenty 36-hour infusions of high-dose methotrexate were given preoperatively to 10 patients with head and neck cancer. Plasma methotrexate levels of greater than 1 X 10(-5) M were maintained for 36 hours and declined with primary and secondary plasma half-lives of 1.7 and 9.2 hours following the end