Initial adjuvant weekly high dose methotrexate with leucovorin rescue in advanced squamous carcinoma of the head and neck
โ Scribed by Ralph R. Weichselbaum; Daniel Miller; Susan W. Pitman; John Kirkwood
- Publisher
- Elsevier Science
- Year
- 1978
- Tongue
- English
- Weight
- 458 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0360-3016
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๐ SIMILAR VOLUMES
## Abstract Eleven patients with squamous carcinoma of the head and neck who were scheduled for surgical resection or endoscopic biopsy of tumor received 15 mg/m^2^ of methotrexate (MTX). Samples of tumor, normal mucosa, and plasma were obtained at surgery or endoscopy, 18โ24 hours after the last M
Twenty 36-hour infusions of high-dose methotrexate were given preoperatively to 10 patients with head and neck cancer. Plasma methotrexate levels of greater than 1 X 10(-5) M were maintained for 36 hours and declined with primary and secondary plasma half-lives of 1.7 and 9.2 hours following the end