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High dose methotrexate with leukovorin rescue as initial adjuvant therapy in advanced local squamous cell carcinoma of the head & neck

✍ Scribed by Ralph R. Weichselbaum; Daniel Miller; Susan Pitman

Publisher: Elsevier Science
Year: 1977
Tongue: English
Weight: 179 KB
Volume: 2
Category: Article
ISSN: 0360-3016
DOI: 10.1016/0360-3016(77)90508-9

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## Background: Induction chemotherapy in locoregionally advanced squamous cell carcinoma of the head and neck (scchn) might improve survival with respect to radiation therapy alone. furthermore, chemotherapy represents the only therapeutic option in metastatic head and neck carcinoma. ## Methods: