High-dose methotrexate with leucovorin rescue in patients with unresectable non-small cell carcinoma of the lung
β Scribed by Martin Brower; Desmond N. Carney; Daniel C. Ihde; Joyce Eddy; Paul A. Bunn; Martin H. Cohen; Francis R. Pelsor; Mary J. Matthews; John D. Minna
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 459 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0008-543X
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π SIMILAR VOLUMES
Forty-one patients with unresectable non-small cell carcinoma of the lung (NSCCL) were treated with cisplatin 20 mg/m2/d for 5 days as a daily bolus injection, 5-fluorouracil 800 mg/m2/d by continuous infusion for 5 days, and intermediate-dose methotrexate 200 mg/m2 on days 15 and 22 of a 28-day cyc
## Background: This study was undertaken to determine whether the use of intermediate dose methotrexate in combination with vinblastine, doxorubicin, and cisplatin as first-line therapy increases the proportion of major responders and overall survival in patients with unresectable or metastatic tra