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Inhibitory role of TGIF in the As2O3-regulated p21WAF1/CIP1expression

✍ Scribed by Zi-Miao Liu; Huei-Sheng Huang

Book ID: 106577137
Publisher: BioMed Central
Year: 2008
Tongue: English
Weight: 476 KB
Volume: 15
Category: Article
ISSN: 1021-7770
DOI: 10.1007/s11373-007-9232-9

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WAF1/Cip1/Sdi1 (p21) is the prototype of a family of proteins that inhibit cyclin-dependent kinases and regulate cell cycle progression in eukaryotic cells. In addition to normal cell cycle progression, p21 is involved in growth suppression mediated by p53 and transforming growth factor beta (TGFbet