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Gambogic acid down-regulates MDM2 oncogene and induces p21Waf1/CIP1 expression independent of p53

✍ Scribed by Jing-Jing Rong; Rong Hu; Qi Qi; Hong-Yan Gu; Qing Zhao; Jia Wang; Rong Mu; Qi-Dong You; Qing-Long Guo

Book ID
116335231
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
931 KB
Volume
284
Category
Article
ISSN
0304-3835

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Data are non-existent regarding coincidental alterations in the expression of p53 and its downstream target genes MDM2 and p21 Waf1/Cip1 in gastric carcinogenesis. An immunohistochemical study was therefore performed to examine the interrelationships of p53, MDM2, and p21 Waf1/Cip1 expression in a s

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Mutations in the p53 tumour suppressor gene are the most common genetic alteration found in human cancers. Most of them are accompanied by stabilization of the protein, which renders it detectable through immunohistochemical techniques. Although p53 expression is a very common finding in Hodgkin's d