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Inhibitory effect of Bcl-2 on p53-mediated transactivation following genotoxic stress

✍ Scribed by Zhan, Qimin; Kontny, Udo; Iglesias, Maite; Jr, Isaac Alamo; Yu, Kelly; Hollander, M Christine; Woodworth, Craig D; Jr, Albert J Fornace

Book ID: 110061768
Publisher: Nature Publishing Group
Year: 1999
Tongue: English
Weight: 388 KB
Volume: 18
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1202310

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## Abstract ## Background and Objectives p53 tumor suppressor gene has a dual role as a trigger of apoptosis and as an initiator of DNA repair. The Bcl‐2 can work to protect cells from apoptosis, which is induced by p53 gene. These facts suggest the significant role of these genes in the genesis a