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Allosteric effects mediate CHK2 phosphorylation of the p53 transactivation domain

✍ Scribed by Craig, Ashley; Scott, Mary; Burch, Lindsay; Smith, Graeme; Ball, Kathryn; Hupp, Ted


Book ID
110034669
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
134 KB
Volume
4
Category
Article
ISSN
1469-221X

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The nonsense-mediated mRNA decay (NMD) mechanism is an evolutionarily conserved process ensuring the degradation of transcripts carrying premature termination codon(s). NMD is believed to prevent the synthesis of truncated proteins that could be detrimental to the cell. However, although numerous st