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Inhibitors of sterol synthesis. Synthesis and spectral properties of 3β-hydroxy-24-dimethylamino-5α-chol-8(14)-en-15-one and its effects on HMG-CoA reductase activity in CHO-K1 cells

✍ Scribed by Josef E. Herz; William K. Wilson; Frederick D. Pinkerton; George J. Schroepfer Jr.


Book ID
107737235
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
604 KB
Volume
60
Category
Article
ISSN
0009-3084

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26-Oxygenated derivatives of As04)-15-ketosterols have been synthesized from (25R)-3#,26-diacetoxy-5a-cholest-8( )-en-15-one (IX) as part of a program to prepare potential metabolites and analogs of 3/~-hydroxy-5c~-cholest-8( )-en-15-one (I), a potent regulator of cholesterol metabolism. Partial hyd

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The enolate of 3B-hydroxy-Sa-cholest-8( )-en-15-one (H), formed upon treatment of H with potassium tert-butoxide in tertbutanol, was alkylated with ethyl iodide. In addition to the major products, 3#-hydroxy-14a-ethyl-5c~-cholest-7-en-15-one and its 38ethyl ether, small amounts of 3#-hydroxy-7c~-eth