(25R)-5 alpha-Cholest-8(14)-ene-3 beta,15 beta,26-triol (III) was prepared by reduction of (25R)-3 beta,26-diacetoxy-5 alpha-cholest-8(14)-en-15-one with sodium borohydride followed by treatment of the crude product with lithium aluminium hydride. The trihydroxysterol III, a potential metabolite of
Inhibitors of sterol synthesis. Synthesis and spectral properties of 3β-hydroxy-24-dimethylamino-5α-chol-8(14)-en-15-one and its effects on HMG-CoA reductase activity in CHO-K1 cells
✍ Scribed by Josef E. Herz; William K. Wilson; Frederick D. Pinkerton; George J. Schroepfer Jr.
- Book ID
- 107737235
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 604 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0009-3084
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📜 SIMILAR VOLUMES
26-Oxygenated derivatives of As04)-15-ketosterols have been synthesized from (25R)-3#,26-diacetoxy-5a-cholest-8( )-en-15-one (IX) as part of a program to prepare potential metabolites and analogs of 3/~-hydroxy-5c~-cholest-8( )-en-15-one (I), a potent regulator of cholesterol metabolism. Partial hyd
The enolate of 3B-hydroxy-Sa-cholest-8( )-en-15-one (H), formed upon treatment of H with potassium tert-butoxide in tertbutanol, was alkylated with ethyl iodide. In addition to the major products, 3#-hydroxy-14a-ethyl-5c~-cholest-7-en-15-one and its 38ethyl ether, small amounts of 3#-hydroxy-7c~-eth