26-Oxygenated derivatives of As04)-15-ketosterols have been synthesized from (25R)-3#,26-diacetoxy-5a-cholest-8( )-en-15-one (IX) as part of a program to prepare potential metabolites and analogs of 3/~-hydroxy-5c~-cholest-8( )-en-15-one (I), a potent regulator of cholesterol metabolism. Partial hyd
Inhibitors of sterol synthesis. Effects of fluorine substitution at carbon atom 25 of cholesterol on its spectral and chromatographic properties and on 3-hydroxy-3-methylglutaryl coenzyme a reductase activity in CHO-K1 cells
โ Scribed by William K. Wilson; Shankar Swaminathan; Frederick D. Pinkerton; Nicolas Gerst; George J. Schroepfer Jr.
- Book ID
- 116065989
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 715 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0039-128X
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๐ SIMILAR VOLUMES
The enolate of 3B-hydroxy-Sa-cholest-8( )-en-15-one (H), formed upon treatment of H with potassium tert-butoxide in tertbutanol, was alkylated with ethyl iodide. In addition to the major products, 3#-hydroxy-14a-ethyl-5c~-cholest-7-en-15-one and its 38ethyl ether, small amounts of 3#-hydroxy-7c~-eth
(25R)-5 alpha-Cholest-8(14)-ene-3 beta,15 beta,26-triol (III) was prepared by reduction of (25R)-3 beta,26-diacetoxy-5 alpha-cholest-8(14)-en-15-one with sodium borohydride followed by treatment of the crude product with lithium aluminium hydride. The trihydroxysterol III, a potential metabolite of