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Inhibitors of Human Immunodeficiency Virus Type 1 (HIV-1) Attachment 13. Synthesis and Profiling of a Novel Amminium Prodrug of the HIV-1 Attachment Inhibitor BMS-585248

โœ Scribed by Regueiro-Ren, Alicia; Simmermacher-Mayer, Jean; Sinz, Michael; Johnson, Kim A.; Huang, Xiaohua Stella; Jenkins, Susan; Parker, Dawn; Rahematpura, Sandhya; Zheng, Ming; Meanwell, Nicholas A.; Kadow, John F.


Book ID
120249331
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
770 KB
Volume
56
Category
Article
ISSN
0022-2623

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Glutathione (GSH) levels are markedly depleted in patients infected with human immunodeficiency virus type 1 (HIV-1) and supplementation of media with high concentrations (5-20 mM) of lowmolecular weight thiols prevents HIV-1 replication in cultured cells. We were intrigued whether chemopreventive e