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Inhibitors of Human Immunodeficiency Virus Type 1 (HIV-1) Attachment 6. Preclinical and Human Pharmacokinetic Profiling of BMS-663749, a Phosphonooxymethyl Prodrug of the HIV-1 Attachment Inhibitor 2-(4-Benzoyl-1-piperazinyl)-1-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoethanone (BMS-488043)

✍ Scribed by Kadow, John F.; Ueda, Yasutsugu; Meanwell, Nicholas A.; Connolly, Timothy P.; Wang, Tao; Chen, Chung-Pin; Yeung, Kap-Sun; Zhu, Juliang; Bender, John A.; Yang, Zhong

Book ID
111691578
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
726 KB
Volume
55
Category
Article
ISSN
0022-2623

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Synthesis of a labeled inhibitor of HIV-
Synthesis of a labeled inhibitor of HIV-1 attachment: 1-(4-benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridinyl-3-yl-[U-14C]ethane-1,2-dione, BMS-488043-14C
✍ I. Victor Ekhato; J. Kent Rinehart 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 118 KB

## Abstract BMS‐488043 is a potent inhibitor of the interaction between HIV‐1 gp120 and the host cell receptor CD4. We prepared the carbon‐14‐labeled version to support preclinical studies of the compound. It was prepared from ethyl [U‐^14^C]oxalyl chloride by a sequence using Friedel–Crafts acylat