Optimizing pharmacokinetic properties to improve oral exposure is a common theme in modern drug discovery. In the present work, in vitro Caco-2 permeability and microsomal half-life screens were utilized in an effort to guide the structure-activity relationship in order to improve the pharmacokineti
Preclinical pharmacokinetics of a novel HIV-1 attachment inhibitor BMS-378806 and prediction of its human pharmacokinetics
✍ Scribed by Zheng Yang; Lisa Zadjura; Celia D'Arienzo; Anthony Marino; Kenneth Santone; Lewis Klunk; Douglas Greene; Pin-Fang Lin; Richard Colonno; Tao Wang; Nicholas Meanwell; Steven Hansel
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 207 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0142-2782
- DOI
- 10.1002/bdd.471
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract CEP‐18770, [(1__R__)‐1‐{[(2__S__,3__R__)‐3‐hydroxy‐2‐{[(6‐phenyl‐2‐pyridinyl)carbonyl]amino}butanoyl]amino}‐3‐methylbutyl]boronic acid, is a novel proteasome inhibitor, now under early clinical evaluation as an anticancer agent. To investigate its clinical pharmacokinetics, a high‐perfo
E‐3810, 6‐[[7‐[(1‐aminocyclopropyl)methoxy]‐6‐methoxy‐4‐quinolyl]oxy]‐__N__‐methyl‐naphthalene‐1‐carboxamide, is a novel, potent, dual inhibitor of vascular endothelial growth factor and fibroblast growth factor receptors with antiangiogenic properties, now under early clinical evaluation as an anti