𝔖 Bobbio Scriptorium
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INHIBITORS OF HIV-1 PROTEASE: A Major Success of Structure-Assisted Drug Design1

✍ Scribed by Wlodawer, Alexander; Vondrasek, Jiri


Book ID
111968199
Publisher
Annual Reviews
Year
1998
Tongue
English
Weight
466 KB
Volume
27
Category
Article
ISSN
1056-8700

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The cocrystal structures of LY289612 and LY297135 were used as a starting point in the design of nonpeptidic HIV-1 protease inhibitors. This report details the discovery of a series of novel aromatic P2 replacement groups. The 3-hydroxy-2-methyl benzoic acid group, discovered in AG1254, was incorpor