Targeting HIV-1 protease: A test of drug-design methodologies
β Scribed by Michael L. West; David P. Fairlie
- Book ID
- 117340814
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 893 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0165-6147
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract To test the anticorrelated relationship that was recently displayed in conventional molecular dynamics (MD) simulations, several different restrained MD simulations on a wild type and on the V82F/I84V drugβresistant mutant of HIVβ1 protease were performed. This anticorrelated relationsh
The cocrystal structures of LY289612 and LY297135 were used as a starting point in the design of nonpeptidic HIV-1 protease inhibitors. This report details the discovery of a series of novel aromatic P2 replacement groups. The 3-hydroxy-2-methyl benzoic acid group, discovered in AG1254, was incorpor