Structure-based drug design of nonpeptid
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Vincent J. Kalish; John H. Tatlock; Jay F. Davies II; Stephen W. Kaldor; Bruce A
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Article
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1995
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Elsevier Science
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English
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The cocrystal structures of LY289612 and LY297135 were used as a starting point in the design of nonpeptidic HIV-1 protease inhibitors. This report details the discovery of a series of novel aromatic P2 replacement groups. The 3-hydroxy-2-methyl benzoic acid group, discovered in AG1254, was incorpor