Inhibitors of GABA metabolism
โ Scribed by Brian W. Metcalf
- Book ID
- 115774757
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- English
- Weight
- 835 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0006-2952
No coin nor oath required. For personal study only.
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## Abstract Stereotaxic injection of kainic acid into rat striatum produces neuronal degeneration and neurochemical alterations resembling Huntington's disease (HD). Since correction of the deficiency in ฮณโaminobutyric acid (GABA) in HD may be of therapeutic value, the efficacy of drugs that inhibi
## Defects in man in four steps of 4aminobutyric acid (GABA) metabolism may interefere with the function of this major inhibitory neurotransmitter. Glutamic acid decarboxylase, 4-aminobutyric acid aminotransferase, succinic semialdehyde dehydrogenase, and homocarnosinase are closely identijied with