𝔖 Bobbio Scriptorium
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3-Isoxazolidone—An inhibitor of GABA metabolism

✍ Scribed by Dennis K.J. Gorecki; Sylvester J. Peesker; James D. Wood


Book ID
115773277
Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
386 KB
Volume
25
Category
Article
ISSN
0006-2952

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## Abstract Stereotaxic injection of kainic acid into rat striatum produces neuronal degeneration and neurochemical alterations resembling Huntington's disease (HD). Since correction of the deficiency in γ‐aminobutyric acid (GABA) in HD may be of therapeutic value, the efficacy of drugs that inhibi