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Inhibitors of farnesylation of Ras from a microbial natural products screening program

✍ Scribed by D Vilella; M Sánchez; G Platas; O Salazar; O Genilloud; I Royo; C Cascales; I Martín; T Díez; K C Silverman; R B Lingham; S B Singh; H Jayasuriya; F Peláez

Book ID
110050808
Publisher
Springer-Verlag
Year
2000
Tongue
English
Weight
241 KB
Volume
25
Category
Article
ISSN
1476-5535

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✍ Sheo B. Singh; Deborah L. Zink; Jerrold M. Liesch; Michael A. Goetz; Rosalind G. 📂 Article 📅 1993 🏛 Elsevier Science 🌐 French ⚖ 702 KB

## Famesyl-Protein transfuase catalyses a post-translational mociificadon of Ras that is obligatory for the cell trarqtorming activity of this oncogene protebt. The screening of natural products to iden@fy inhibitors of this enzyme as a potential anticancer agents. has led to the isolation #two nove