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Inhibitors of cholesterol biosynthesis. 4. trans-6-[2-(Substituted-quinolinyl)ethenyl/ethyl]tetrahydro-4-hydroxy-2H-pyran-2-ones, a novel series of HMG-CoA reductase inhibitors

โœ Scribed by Sliskovic, D. R.; Picard, J. A.; Roark, W. H.; Roth, B. D.; Ferguson, E.; Krause, B. R.; Newton, R. S.; Sekerke, C.; Shaw, M. K.


Book ID
120494772
Publisher
American Chemical Society
Year
1991
Tongue
English
Weight
877 KB
Volume
34
Category
Article
ISSN
0022-2623

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Enantioselective synthesis of the lacton
โœ Toshio Honda; Satoko Ono; Hirotake Mizutani; Keith O. Hallinan ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 217 KB

The enantioselective synthesis of the lactone moiety of (+)-compactin and (+)mevinolin was established starting from a meso-3,5-dihydroxycyclohexanone derivative by employing an enantioselective deprotonation strategy. (~