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Enantioselective synthesis of the lactone moiety of HMG-CoA reductase inhibitor: stereoselective synthesis of (+)-(4R,6R)-4-hydroxy-6-(2-phenylethyl)-tetrahydro-2H-pyran-2-one

✍ Scribed by Toshio Honda; Satoko Ono; Hirotake Mizutani; Keith O. Hallinan

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 217 KB
Volume: 8
Category: Article
ISSN: 0957-4166
DOI: 10.1016/s0957-4166(96)00525-3

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✦ Synopsis

The enantioselective synthesis of the lactone moiety of (+)-compactin and (+)mevinolin was established starting from a meso-3,5-dihydroxycyclohexanone derivative by employing an enantioselective deprotonation strategy. (~

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