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ChemInform Abstract: Stereoselective Total Synthesis of a Potent Natural Antifungal Compound (6S)-5,6,Dihydro-6-[(2R)-2-hydroxy-6-phenyl hexyl]-2H-pyran-2-one.

โœ Scribed by Biswanath Das; Keetha Laxminarayana; Martha Krishnaiah; Duddukuri Nandan Kumar


Publisher
John Wiley and Sons
Year
2010
Weight
38 KB
Volume
41
Category
Article
ISSN
0931-7597

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The Stereoselective Total Synthesis of (
โœ Jhilluโ€…Singh Yadav; Dandekar Chandrakanth; Yerragorlaโ€…Gopala Rao; Kontham Ravind ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ German โš– 180 KB

## Abstract The stereoselective total synthesis of an antiproliferative and antifungal __ฮฑ__โ€pyrone natural product (6__S__)โ€5,6โ€dihydroโ€6โ€[(2__R__)โ€2โ€hydroxyโ€6โ€phenylhexyl]โ€2__H__โ€pyranโ€2โ€one is described. The key steps involved are the __Prins__ cyclization, __Mitsunobu__ reaction, and ringโ€closi