𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Inhibitors of acyl-CoA:cholesterol acyltransferase. 5. Identification and structure-activity relationships of novel .beta.-keto amides as hypocholesterolemic agents

✍ Scribed by Augelli-Szafran, Corinne E.; Blankley, C. John; Roth, Bruce D.; Trivedi, Bharat K.; Bousley, Richard F.; Essenburg, Arnold D.; Hamelehle, Katherine L.; Krause, Brian R.; Stanfield, Richard L.


Book ID
127355528
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
930 KB
Volume
36
Category
Article
ISSN
0022-2623

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Inhibitors of acyl-CoA: cholesterol O-ac
✍ D.R. Sliskovic; J.A. Picard; W.H. Roark; A.D. Essenburg; B.R. Krause; L.L. Minto πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 332 KB

The synthesis and structure-activity relationships of a series of malonester amide ACAT inhibitors are described. One of these compounds, 4s, was shown to be a potent inhibitor of both the intestinal and arterial enzymes, bioactive upon oral dosing (ex vivo bioassay) and efficacious in a clinically