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Inhibition of the rapid component of the delayed-rectifier K+ current by therapeutic concentrations of the antispasmodic agent terodiline

✍ Scribed by Stephen E Jones; Toshitsugu Ogura; Lesya M Shuba; Terence F McDonald

Book ID
110003936
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
303 KB
Volume
125
Category
Article
ISSN
0007-1188

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πŸ“œ SIMILAR VOLUMES

Development of pharmacophores for inhibi
Development of pharmacophores for inhibitors of the rapid component of the cardiac delayed rectifier potassium current
✍ PΓ©ter MΓ‘tyus; AndrΓ‘s P. Borosy; AndrΓ‘s VarrΓ³; Julius G. Papp; Daniela Barlocco; πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 343 KB

Blockade of cardiac-delayed rectifier potassium current I is an Kr important mechanism for Class III antiarrhythmic effect. We developed pharmacophores for I inhibitors starting from structures of known blockers. To obtain the Kr pharmacophores, DISCO module of SYBYL was used. Conformations required