Development of pharmacophores for inhibi
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PΓ©ter MΓ‘tyus; AndrΓ‘s P. Borosy; AndrΓ‘s VarrΓ³; Julius G. Papp; Daniela Barlocco;
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Article
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1998
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John Wiley and Sons
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English
β 343 KB
Blockade of cardiac-delayed rectifier potassium current I is an Kr important mechanism for Class III antiarrhythmic effect. We developed pharmacophores for I inhibitors starting from structures of known blockers. To obtain the Kr pharmacophores, DISCO module of SYBYL was used. Conformations required