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Deciphering hERG channels: Molecular basis of the rapid component of the delayed rectifier potassium current

✍ Scribed by Malin K.B. Jonsson; Marcel A.G. van der Heyden; Toon A.B. van Veen

Book ID
118506970
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
429 KB
Volume
53
Category
Article
ISSN
0022-2828

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✍ PΓ©ter MΓ‘tyus; AndrΓ‘s P. Borosy; AndrΓ‘s VarrΓ³; Julius G. Papp; Daniela Barlocco; πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 343 KB

Blockade of cardiac-delayed rectifier potassium current I is an Kr important mechanism for Class III antiarrhythmic effect. We developed pharmacophores for I inhibitors starting from structures of known blockers. To obtain the Kr pharmacophores, DISCO module of SYBYL was used. Conformations required