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Adrenergic regulation of the rapid component of the cardiac delayed rectifier potassium current, IKr, and the underlying hERG ion channel

✍ Scribed by Dierk Thomas; Johann Kiehn; Hugo A. Katus; Christoph A. Karle

Publisher
Springer
Year
2004
Tongue
English
Weight
120 KB
Volume
99
Category
Article
ISSN
0300-8428

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Development of pharmacophores for inhibi
Development of pharmacophores for inhibitors of the rapid component of the cardiac delayed rectifier potassium current
✍ Péter Mátyus; András P. Borosy; András Varró; Julius G. Papp; Daniela Barlocco; 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 343 KB

Blockade of cardiac-delayed rectifier potassium current I is an Kr important mechanism for Class III antiarrhythmic effect. We developed pharmacophores for I inhibitors starting from structures of known blockers. To obtain the Kr pharmacophores, DISCO module of SYBYL was used. Conformations required