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Inhibition of the HERG K+ channel by the antifungal drug ketoconazole depends on channel gating and involves the S6 residue F656

✍ Scribed by John M. Ridley; James T. Milnes; Rona S. Duncan; Mark J. McPate; Andrew F. James; Harry J. Witchel; Jules C. Hancox

Book ID
116466495
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
402 KB
Volume
580
Category
Article
ISSN
0014-5793

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## Abstract A number of clinically used drugs block delayed rectifier K^+^ channels and prolong the duration of cardiac action potentials associated with long QT syndrome. This study investigated the molecular mechanisms of voltage‐dependent inhibition of human ether‐__a‐go‐go__‐related gene (HERG)