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hERG K+ channel blockade by the antipsychotic drug thioridazine: An obligatory role for the S6 helix residue F656

โœ Scribed by James T. Milnes; Harry J. Witchel; Joanne L. Leaney; Derek J. Leishman; Jules C. Hancox


Book ID
116293816
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
402 KB
Volume
351
Category
Article
ISSN
0006-291X

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## Abstract A number of clinically used drugs block delayed rectifier K^+^ channels and prolong the duration of cardiac action potentials associated with long QT syndrome. This study investigated the molecular mechanisms of voltageโ€dependent inhibition of human etherโ€__aโ€goโ€go__โ€related gene (HERG)