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High affinity HERG K+ channel blockade by the antiarrhythmic agent dronedarone: resistance to mutations of the S6 residues Y652 and F656

✍ Scribed by John M. Ridley; James T. Milnes; Harry J. Witchel; Jules C. Hancox

Book ID
116289471
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
482 KB
Volume
325
Category
Article
ISSN
0006-291X

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## Abstract A number of clinically used drugs block delayed rectifier K^+^ channels and prolong the duration of cardiac action potentials associated with long QT syndrome. This study investigated the molecular mechanisms of voltage‐dependent inhibition of human ether‐__a‐go‐go__‐related gene (HERG)