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Inhibition of telomerase activity by dominant-negative hTERT retards the growth of breast cancer cells

✍ Scribed by Rao, Yaojian; Xiong, Wei; Liu, Huijuan; Jia, Chunxia; Zhang, Hongxing; Cui, Zesheng; Zhang, Ya; Cui, Jiawei

Book ID
125833866
Publisher
Springer Japan
Year
2014
Tongue
English
Weight
462 KB
Volume
23
Category
Article
ISSN
1340-6868

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## Abstract Ribozyme possesses specific endoribonuclease activity and catalyzes the hydrolysis of specific phosphodiester bonds, which results in the cleavage of target RNA sequences. Here, we evaluated the ability of hammerhead ribozymes targeting human telomerase RNA (hTR) to inhibit the catalyti