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Inhibition of steroid sulphatase activity by tricyclic coumarin sulphamates

✍ Scribed by B. Malini; A. Purohit; D. Ganeshapillai; L.W.L. Woo; B.V.L. Potter; M.J. Reed

Book ID
117668113
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
118 KB
Volume
75
Category
Article
ISSN
0960-0760

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## Abstract Many tumours in endocrine‐sensitive tissues, such as the breast and endometrium, are hormone‐dependent and the hydrolysis of oestrone sulphate (EIS) to oestrone by oestrone sulphatase (EI‐STS) is a major source of oestrogen in such tumours. Oestrone‐3‐O‐sulphamate (EMATE) has been shown