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Inhibition of Serum- and Calcium-Induced Differentiation of Human Keratinocytes by HPV16 E6 Oncoprotein: Role of p53 Inactivation

✍ Scribed by Levana Sherman; Anna Jackman; Hagar Itzhaki; Melissa Conrad Stöppler; Debbie Koval; Richard Schlegel

Book ID
112271732
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
408 KB
Volume
237
Category
Article
ISSN
0042-6822

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Human papillomavirus type 16 E6 and HPV-16 E6/E7 sensitize human keratinocytes to apoptosis induced by chemotherapeutic agents: Roles of p53 and caspase activation
✍ Yongmin Liu; Ann McKalip; Brian Herman 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 583 KB

We and others have previously reported that human papillomavirus (HPV)-16 E6 protein expression sensitizes certain cell types to apoptosis. To confirm that this sensitization occurred in HPV's natural host cells, and to explore the mechanism(s) of sensitization, we infected human keratinocytes (HKCs