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Inhibition of Serum- and Calcium-Induced Terminal Differentiation of Human Keratinocytes by HPV 16 E6: Study of the Association with p53 Degradation, Inhibition of p53 Transactivation, and Binding to E6BP

✍ Scribed by Levana Sherman; Hagar Itzhaki; Anna Jackman; Jason J. Chen; Debbie Koval; Richard Schlegel

Book ID
112273879
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
392 KB
Volume
292
Category
Article
ISSN
0042-6822

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Human papillomavirus type 16 E6 and HPV-
Human papillomavirus type 16 E6 and HPV-16 E6/E7 sensitize human keratinocytes to apoptosis induced by chemotherapeutic agents: Roles of p53 and caspase activation
✍ Yongmin Liu; Ann McKalip; Brian Herman πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 583 KB

We and others have previously reported that human papillomavirus (HPV)-16 E6 protein expression sensitizes certain cell types to apoptosis. To confirm that this sensitization occurred in HPV's natural host cells, and to explore the mechanism(s) of sensitization, we infected human keratinocytes (HKCs