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Inhibition of Receptor Activator of NF-κB Ligand by Denosumab Attenuates Vascular Calcium Deposition in Mice

✍ Scribed by Susann Helas; Claudia Goettsch; Michael Schoppet; Ute Zeitz; Ute Hempel; Henning Morawietz; Paul J. Kostenuik; Reinhold G. Erben; Lorenz C. Hofbauer

Book ID
117970925
Publisher
American Society for Investigative Pathology
Year
2009
Tongue
English
Weight
732 KB
Volume
175
Category
Article
ISSN
0002-9440

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## Abstract Expression of the cytokine, receptor activator of NF‐κB ligand (RANKL), is stimulated by both parathyroid hormone (PTH) and calcitriol in osteoblasts. Most studies have examined the effects on RANKL mRNA, and less information is available on the protein products. We have determined the